Towards Affordable Biomedical Imaging: Recent Advances in Low-Cost, High-Resolution Optoacoustic Microscopy
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Problem:
Optoacoustic microscopy (OAM) is a powerful imaging technique that combines optical and acoustic methods to provide high-resolution images of biological tissues. However, the widespread adoption of OAM in biomedical research and clinical settings has been limited due to the high cost and complexity of traditional systems, which typically rely on expensive Q-switched nanosecond laser sources. This financial barrier restricts access to advanced imaging technologies, particularly in resource-limited settings.
Methodology:
Recent advancements have focused on developing low-cost, high-resolution OAM systems by integrating laser diodes for signal excitation. Laser diodes are significantly more affordable—20 to 40 times cheaper—than traditional laser sources. This review discusses implementations of laser diode-based OAM in both time and frequency domains, highlighting their applications in biomedical research. Notable applications include microvasculature imaging, oxygen saturation assessments, hybrid and multiview microscopy of model organisms and tissues, and Doppler flow speed measurements.
Solution:
The integration of laser diodes into OAM systems has led to the development of cost-effective, robust, and portable imaging solutions. These systems enhance multispectral capabilities and overall imaging performance, making advanced imaging techniques more accessible for biomedical research. By reducing costs and improving functionality, laser diode-based OAM systems have the potential to democratize access to high-resolution imaging, facilitating broader adoption in various research and clinical environments.