Spermidine is Essential for Fasting-Mediated Autophagy and Longevity
You can find the publication text here:
Problem:
The aging process and associated diseases often correlate with reduced cellular function and accumulation of damaged components. Fasting and caloric restriction are widely known to extend lifespan and promote health, but the molecular mechanisms underlying these benefits remain incompletely understood. Identifying key mediators that link fasting to cellular and systemic health could open avenues for targeted therapies in age-related disorders.
Methodology:
This study investigates the role of spermidine, a polyamine, in fasting-induced autophagy and longevity. Researchers used multiple model organisms, including yeast, flies, mice, and humans, to measure spermidine levels during fasting. They analyzed the role of spermidine in hypusination, a specific biochemical modification of the translation factor eIF5A, essential for autophagy induction. Spermidine synthesis was blocked in some models to assess its impact on autophagy and lifespan.
Solution:
The research reveals that fasting elevates spermidine levels, which are critical for triggering autophagy and the lifespan extension associated with fasting. Furthermore, hypusination mediated by spermidine was identified as a conserved mechanism required for these benefits. These findings highlight spermidine as a potential therapeutic target to mimic fasting’s health benefits without dietary restrictions, offering exciting possibilities for treating aging and metabolic disorders.